Gene information
Official symbol CXCR4
Official full name C-X-C motif chemokine receptor 4
Gene type protein-coding gene
Chromosome2q22.1
Alias symbolLESTR; NPY3R; HM89; NPYY3R; D2S201E; fusin; HSY3RR; NPYR; CD184
Gene familyCD molecules; C-X-C motif chemokine receptors
Resources
Entrez Gene 7852
HGNC HGNC:2561
Ensembl ENSG00000121966
Vega OTTHUMG00000153583
UCSC uc002tuy.3
GO terms: 132 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001637 G protein-coupled chemoattractant receptor activity GO Molecular Functions -4.13020121 7 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0002407 dendritic cell chemotaxis GO Biological Processes -5.31723275 7 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003015 heart process GO Biological Processes -12.3962712 26 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0003779 actin binding GO Molecular Functions -9.68875312 26 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0004950 chemokine receptor activity GO Molecular Functions -4.13020121 7 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006936 muscle contraction GO Biological Processes -17.3443769 27 More
GO:0006941 striated muscle contraction GO Biological Processes -9.86033061 14 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007009 plasma membrane organization GO Biological Processes -3.91866373 17 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007272 ensheathment of neurons GO Biological Processes -4.19306733 15 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008037 cell recognition GO Biological Processes -2.17557915 8 More
GO:0008366 axon ensheathment GO Biological Processes -4.19306733 15 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009581 detection of external stimulus GO Biological Processes -2.05740021 12 More
GO:0009582 detection of abiotic stimulus GO Biological Processes -2.39356289 13 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014015 positive regulation of gliogenesis GO Biological Processes -11.0528361 19 More
GO:0014823 response to activity GO Biological Processes -19.5783025 27 More
GO:0015026 coreceptor activity GO Molecular Functions -2.48314997 7 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016048 detection of temperature stimulus GO Biological Processes -2.54763391 5 More
GO:0016493 C-C chemokine receptor activity GO Molecular Functions -4.51081372 7 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0019956 chemokine binding GO Molecular Functions -7.24411974 11 More
GO:0019957 C-C chemokine binding GO Molecular Functions -4.37707433 7 More
GO:0021537 telencephalon development GO Biological Processes -6.21909725 29 More
GO:0021885 forebrain cell migration GO Biological Processes -5.92071483 13 More
GO:0022029 telencephalon cell migration GO Biological Processes -5.36863544 12 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031625 ubiquitin protein ligase binding GO Molecular Functions -1.82192201 21 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0036336 dendritic cell migration GO Biological Processes -5.26554247 8 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042552 myelination GO Biological Processes -4.28583448 15 More
GO:0043217 myelin maintenance GO Biological Processes -5.31723275 7 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043279 response to alkaloid GO Biological Processes -4.89883771 15 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044389 ubiquitin-like protein ligase binding GO Molecular Functions -1.61071129 9 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0045685 regulation of glial cell differentiation GO Biological Processes -7.97684638 17 More
GO:0045687 positive regulation of glial cell differentiation GO Biological Processes -7.00526019 12 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0048713 regulation of oligodendrocyte differentiation GO Biological Processes -5.35296451 10 More
GO:0048714 positive regulation of oligodendrocyte differentiation GO Biological Processes -3.64344566 6 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050792 regulation of viral process GO Biological Processes -4.90676471 20 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0050951 sensory perception of temperature stimulus GO Biological Processes -3.21663541 6 More
GO:0050954 sensory perception of mechanical stimulus GO Biological Processes -4.15913068 20 More
GO:0050961 detection of temperature stimulus involved in sensory perception GO Biological Processes -3.03478521 5 More
GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO Biological Processes -3.41433421 5 More
GO:0050982 detection of mechanical stimulus GO Biological Processes -3.60984508 9 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060047 heart contraction GO Biological Processes -8.83781505 20 More
GO:0060048 cardiac muscle contraction GO Biological Processes -7.88412825 17 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061043 regulation of vascular wound healing GO Biological Processes -4.91299256 6 More
GO:0062149 detection of stimulus involved in sensory perception of pain GO Biological Processes -4.25041921 7 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04672 Intestinal immune network for IgA production KEGG Pathway -7.87779205 9 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 20 records
Drug name Interaction type Source PMID View
balixafortide TTD view
bevacizumab PharmGKB 27503580 view
bkt140 antagonist TdgClinicalTrialChemblInteractionsTTD view
burixafor antagonist TdgClinicalTrialChemblInteractionsTTD view
chembl1221944 DTC 17643111 view
chembl1242210 DTC 19949058 view
chembl2062277 DTC 19451305 view
chembl2347630 DTC 23434419 view
chembl2347631 DTC 23434419 view
chembl2347632 DTC 23434419 view
chembl2347633 DTC 23434419 view
cisplatin CIViC 27922681 view
ctce-9908 antagonist ChemblInteractionsTTD view
mavorixafor antagonist DTCTdgClinicalTrialTTD 19640718 view
msx-122 antagonist TdgClinicalTrialChemblInteractionsTTD view
pf-06747143 TTD view
plerixafor partial agonistantagonist DTCTdgClinicalTrialChemblInteractionsNCITENDTTD 17715128188473131158137623204107194513051795834426191361 view
pol6326 antagonist ChemblInteractionsTTD view
ulocuplumab antibody TTD view
usl-311 TTD view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
C-X-C chemokine receptor type 4 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Abdallah KO et al. Egypt J Immunol. 2014
C-X-C chemokine receptor type 4 proteomics platelet survival[other] acute ST elevation myocardial infarction Rath D et al. Atherosclerosis. 2018
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